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The latest International Myeloma Working Group (IMWG) guideline recommends low-dose whole-body (W computed tomography (CT) as the first-line imaging technique for the initial diagnosis of plasma cell disorders. To evaluate diagnostic performances of CT and diffusion-weighted imaging (DWI) as the first-line imaging modalities and assess misclassification rates obtained following the guideline. Two independent radiologists analyzed CT (acquired as PET/CT) and DWI (3-T; b-values = 50 and 900 s/mm ) of patients newly diagnosed with plasm