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Treatment For ADHD The most effective treatment options for add are medications and psychosocial therapy (psychotherapy). Medications can include stimulants like amphetamine and methylphenidate, and nonstimulants like atomoxetine, viloxazine, guanfacine, clonidine and gu. Patients with active substance abuse issues are not advised to take stimulant medication. However, those in stable remission might look into them. Combination therapy using antidepressants especially SSRIs, is a different option.