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4 to 2.9 mL∙100g∙min-1). A clinically relevant increase in VI muscle perfusion after immersion at 8°C and a decrease in RF muscle perfusion at 15°C were observed. A clinically relevant increase in perfusion was observed in the VI in 8°C compared with 22°C water (2.3 mL∙100g∙min-1; 1.1 to 3.5 mL∙100g∙min-1). There were no clinically relevant between-condition differences in thigh CVC. Our findings suggest that CWI (8-22°C) does not reduce global quadriceps muscle perfusion to a clinically relevant extent, however, colder-water (8°C) increa