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Moreover, macrophages-related functions corresponded more to the disease severity compared to T cells-related functions. Our findings more proficiently dissected the transcriptomic changes leading to the severity of a COVID-19 infection.With the aim of improving the reconstruction of stochastic evolution equations from empirical time-series data, we derive a full representation of the generator of the Kramers-Moyal operator via a power-series expansion of the exponential operator. This expansion is necessary for deriving th

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Sixty-five drug candidates were screened out, most substructures of which are similar to these of existing oral drugs. Candidates screened from S-GDB13 have higher similarity to existing drugs and better molecular docking performance than those from the rest of GDB-13. The screening speed on S-GDB13 is significantly faster than screening directly on GDB-13. In general, D-GCAN is a promising tool to predict the drug-likeness for selecting potential candidates and accelerating drug discovery by excluding unpromising candidates and avoidin