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BACKGROUND RNA methylation is a reversible post-transcriptional modification involving numerous biological processes. Ribose 2'-O-methylation is part of RNA methylation. It has shown that ribose 2'- O-methylation plays an important role in immune recognition and other pathogenesis. OBJECTIVE We aim to design a computational method to identify2'-O-methylation. METHOD Different from the experimental method, we propose a computational workflow identifying the methylation site based on the multi-feature extracting algorithm. RESULTS With a