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Tissue α-E-catenin immunohistochemistry was performed on CTNNA1 c.1351CT (p.Arg451*) carriers. RESULTS Fifty-two individuals (0.03% tested) had CTNNA1 loss-of-function (LOF) variations and 1057 people (0.7% tested) had a complete of 302 distinct missense variants of uncertain value. Detailed history ended up being offered on 33 CTNNA1 LOF carriers, with 21 unique CTNNA1 LOF variations. Four (12%) individuals had diffuse gastric disease and 22 (67%) had ca