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REM-related obstructive sleep apnea (REM-OSA), as defined using revised apnea-hypopnea index (AHI) criteria, might represent a specific OSA phenotype. However, there is a lack of data on outcomes of treatment in this population. This study evaluated the effects of CPAP treatment over 12months on clinical outcomes for patients with the polysomnography phenotype of REM-OSA. We conducted a prospective observational study with the following inclusion criteria subjective sleepiness and diagnostic polysomnography demonstrating AHI ≥15 events/