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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can cause chronic underachievement and depression. This is particularly true when they fail their personal and professional objectives. The overlap of symptoms from the comorbidities of ADHD and depression can make it difficult to make a clear diagnosis. However, identifying the signs is the first step towards finding treatment. 1. Feelings of inadequa