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3% (95% CI 66.1-70.4) and 76.3% (95% CI 74.0-78.5) respectively. Risk factors associated with new chronic post-operative opioid use included female gender, underweight and obesity, pre-operative comorbidities, acute surgery, ICU-time1day, and post-operative complications. Strongest predictor of chronic post-operative opioid use was post-discharge use of opioid within one month after surgery (odds ratio 3.3, 95% CI 2.8-4.. New chronic post-operative opioid use after open cardiac surgery is common. Focus on post-discharge opioid use