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Furthermore, when analyzed by Nanostring immune profiling treatment of Debio-025 with anti-PD1 mAb increased both T cell signaling and innate immune signaling in TME. Implications These data suggest that pharmacological inhibition of CypA may provide a promising and unanticipated consequence in cancer biology, in part by targeting the CypA/Crk II axis that regulates cell migration, tumor metastasis, and host anti-tumor immune evasion. Copyright ©2020, American Association for Cancer Research.OBJECTIVE To define and validate criteria fo