https://www.selleckchem.com/pr....oducts/NVP-TAE684.ht
PURPOSE Fluence-modulated proton computed tomography (FMpCT) using pencil beam scanning aims at achieving task-specific image noise distributions by modulating the imaging proton fluence spot-by-spot based on an object-specific noise model. In this work, we present a method for fluence field optimization and investigate its performance in dose reduction for various phantoms and image variance targets. METHODS The proposed method uses Monte Carlo simulations of a proton CT (pCT) prototype scanner to estimate expected variance levels a