https://www.selleckchem.com/pr....oducts/guanidine-thi
To appraise the validity of the Yaakov Stern's theory, which postulates that the first cognitive deficits of Alzheimer's disease are delayed in patients with high cognitive reserve, compared to those with low cognitive reserve, but is subsequently associated with faster cognitive decline when cerebral lesions have reached some degree of severity. A retrospective study of 318 patients with Alzheimer's disease without associated cerebral disorders, was performed in the Memory Clinic of the University Hospital of Strasbourg.

https://www.selleckchem.com/pr....oducts/amg-perk-44.h
In murine and canine animal models, mutations in the Arylsulfatase G gene (ARSG) cause a particular lysosomal storage disorder characterized by neurological phenotypes. Recently, two variants in the same gene were found to be associated with an atypical form of Usher syndrome in humans, leading to visual and auditory impairment without the involvement of the central nervous system. In this study, we identified three novel pathogenic variants in ARSG, which segregated recessively with the disease in two families from Portugal. The pr