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iofrequency balloon catheter allowed visually guided, directional titration of ablative energy to safely isolate PVs with short procedure times. Registration URL https//www.anzctr.org.au; Unique identifier ACTRN12615001340527.Background PKARIα (protein kinase A type I-α regulatory subunit) is redox-active independent of its physiologic agonist cAMP. However, it is unknown whether this alternative mechanism of PKARIα activation may be of relevance to cardiac excitation-contraction coupling. Methods and Results We used a redox-dead transgen