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The subgroup analysis revealed that the prevalence estimates of fear-related symptoms were consistently high. Medical staff during the COVID-19 epidemic have a high prevalence of adverse mental health symptoms. Data-based strategies are needed to optimize mental health of medical staff and other health care professionals during times of high demand such as the COVID-19 and other epidemics.PROSPERO Registration CRD42020182433. Medical staff during the COVID-19 epidemic have a high prevalence of adverse mental health sympto