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from the risk factors in the general population, which suggests the need for tailored suicide prevention strategies. The BEACON trial showed that combination therapy with encorafenib (BRAF inhibitor) and cetuximab (EGFR inhibitor) was associated with prolonged overall survival compared with standard chemotherapy in patients with metastatic BRAF variant colorectal cancer. However, the cost-effectiveness of using these agents in this clinical setting is unknown. To create a cost-effectiveness model to compare doublet therapy (encorafenib