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Differential expressed genes involved in auxin, ethylene, brassinosteroid and ABA signalling formed signal transduction cascades, which interacted with hub transcription factors, thereby finally orchestrated the expression of multiple genes associated with cell wall and membrane stability, cell elongation and Cd tolerance, including IAAs, ARFs, SnRK2, PP2C, PIFs, BES1/BZR1, CCR, CAD, FATB, fabF and HACD. Additionally, post-transcriptional modification of CIPKs, MAPKs, WAXs, UBCs, and E3 ubiquitin ligases were identified and also involved