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RIP and luciferase reporter gene assay suggested a direct interaction between miR-92b-3p and HIF-1α, and overexpression of miR-92b-3p could inhibit the expression of HIF-1α, RhoA and ROCK activity. Upregulated miR-92b-3p partially reduced inflammatory cytokines, inhibited pulmonary remodeling, and thus alleviating the hypoxic PH. miR-92b-3p could alleviate the hypoxia-induced PH. Our findings offer basis for better understanding the role of miRNAs in PH. Our findings offer basis for better understanding the role of miRNAs in PH. Pneumoni
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