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entry pathway, E30 accumulates in classical early endosomes. Copyright © 2020 American Society for Microbiology.Histone deacetylase inhibitors (HDACi) are the most widely studied HIV latency reversing agents (LRAs). The HDACi suberoylanilidehydroxamic acid (vorinostat, VOR) has been employed in several clinical HIV latency reversal studies as well as in vitro models of HIV latency and shown to effectively induce HIV RNA and protein expression. Despite these findings, response to HDACi can vary, particularly with intermittent dosing, and in