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Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-m