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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the first-choice ADHD medications, they with the most research behind them, and they are quick-acting. However, they're not suitable for everyone. These medications increase the signaling between nerves and areas in the brain to lessen symptoms of ADHD. These medications can also trigger side-effects like a change in heart rate or blood pressure and an increase in appetite. Stimulants The most common medication used to treat ADHD is stimulants. They're known for improving the quality