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Elevated TyG index increases the risk of CIIS and SC-MI, which could be a new biomarker in the clinical practice. Heart failure (HF) and cancer are currently two leading causes of mortality, and sometimes coexist. However, the relationship between them is not completely elucidated. We aimed to investigate whether patients with HF are predisposed to cancer development using the large Korean National Health Insurance claims database. This study included 128,441 HF patients without a history of cancer and 642,205 age- and sex-matched indiv