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Interestingly, F1 formulation of niosomal Imipenem indicated cell viability over 90% at all tested concentrations. The results of the present study indicate that Niosome-encapsulated Imipenem reduces the resistance of MRSE to antibiotics in addition to increasing its anti-biofilm and antibiotic activity, and could prove useful as a new strategy for drug delivery.Scarce freshwater resources in arid and semiarid regions means that recreational landscapes should use recycled or low-quality waters for irrigation, increasing the risk of salini