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AS-IV down-regulated the appearance of inflammatory genetics and up-regulated the expressions of anti-oxidant genetics in GDM mice model. AS-IV treatment reduced cAMP buildup in liver and reduced hepatic gluconeogenesis in GDM mice. Conclusion This study demonstrated that AS-IV treatment has actually a fruitful healing purpose of GDM in mice design through the regulation of cAMP accumulation and hepatic gluconeogenesis.Myocardial ischemia reperfusion damage (MIRI) could be t