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Physicians need to be vigilant about vitamin B12 levels in patients with conversion symptoms. To evaluate the efficacy of current practices and new modalities for the management of neonatal indirect hyperbilirubinaemia. The prospective study was conducted at King Khalid Hospital, Al Majmaah, Saudi Arabia, from September 2015 to September 2018, and copmprised neonates with hyperbilirubinaemia who were managed using the National Institute for Health and Clinical Excellence 2010 guidelines. The outcomes were measured in terms of decrease in