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Also, combining UDCA aided by the proteasome inhibitor bortezomib (BTZ) achieved a synergistic impact through enhancing the PERK/ATF4/CHOP pathway and protracting ER tension. UDCA inhibited GBM progression, additionally the combination with BTZ realized a synergistic result via protracted ER stress. Thus, UDCA, alone or with mix of BTZ, shows guarantee as a possible therapeutic representative for the treatment of GBM.Clostridioides difficile (C. difficile) illness (CDI) is the major reason behind nosocomial an