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Piperine (1-piperoyl piperidine), a major alkaloid constituent of L. and L. has pleiotropic biological effects, but the mechanism(s) involved remain to be elucidated. The current study was conducted to examine the efficacy of antioxidant ability of piperine on t-BHP induced markers of oxidative stress in human erythrocytes. Healthy human erythrocytes and erythrocytes membrane was stressed with free radical inducer chemical; BHP (10 M), and the effects of piperine was measured against free radical mediated modification in lipid and protein