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The effects of the neurodegenerative processes at a macroscopic degree are quantified by estimation of mind and spinal-cord atrophy with MRI. MRI dimensions of atrophy in MS have also suggested as a complementary way of lesion assessment to facilitate the forecast of clinical outcomes and also to examine therapy answers. In this Consensus declaration, the Magnetic Resonance Imaging in MS (MAGNIMS) study group critically review the application of brain and spinal cord atrophy in clinical