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Stage-specific embryonic antigen-4 (SSEA-4) expression is associated with malignant aggressiveness and is useful as a marker for identifying cancer stem cells. Our aim was to assess the relationship between hormonal therapy and SSEA-4 expression in prostate cancer (PC). SSEA-4 expression in paired specimens from PC patients who underwent neoadjuvant hormonal therapy (NHT) and radical prostatectomy (60 pre-NHT specimens and 60 post-NHT specimens) was evaluated using immunohistochemistry. Proliferation index (PI) and apoptotic index (AI) w

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Adult ADHD Signs and Symptoms Finding out that you have adult ADHD can help relieve feelings of guilt, shame or failure. Many people are relieved to know the reason behind their difficulties in life particularly if they have been thought of as lazy or irresponsible. To be eligible for a diagnosis of ADHD to be established, symptoms must have appeared before the age of 12. In addition, the symptoms are significant in at minimum two settings (home school, work and home). These criteria are important because