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ADHD Treatment For Adults - Stimulant Medication Stimulant medications like methylphenidate and dextroamphetamine are typically considered the first-line therapy for adult ADHD. These drugs increase and balance brain chemicals called neurotransmitters. Nonstimulant and antidepressant medications like atomoxetine are often prescribed when stimulants aren't appropriate for the patient due to other health issues or adverse effects. These med