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Overall, these findings suggest that bioflocs could regulate the activation of Nrf2 and protect acute copper exposure induced inflammatory response by inhibiting the NF-κB signaling pathway in R. lagowski. The present study was conducted to investigate the effects of CoQ10 dietary supplementation on growth performance, feed utilization, blood profile, immune response, and oxidative status of Nile tilapia (12.4 ± 0.11 g, initial body weight). Five experimental diets were formulated containing CoQ10 at levels of 0, 10, 20, 30, 40 mg kg-1 d