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ADHD Treatment For Adults The stimulants like methylphenidate amphetamine, and other brain chemicals can help increase levels. Nonstimulants like atomoxetine or antidepressants are slower than stimulants, but they may be just as beneficial. Complicating conditions often affect the effectiveness of ADHD medication. Doctors should treat the most severe symptom of any comorbid disorder first, and then examine whether the ADHD symptoms improve. Medication Medication is the most common form of treatment for adults wi