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Sildenafil-mediated synergistic effects were mimicked by other PDE5 inhibitors including vardenafil and tadalafil, and also by PDE5A knockdown in cells, suggesting PDE5-involved mechanism. Notably, sildenafil amplified vincristine-induced phosphorylation and cleavage of BUBR1, a protein kinase in spindle assembly checkpoint (SAC) function and chromosome segregation. Sildenafil also significantly decreased kinetochore tension during SAC activation. Moreover, sildenafil synergized with vincristine on suppressing tumor growth in a

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Vehicle Key Repairs You Shouldn't Do Yourself It can be a real pain when your car key stops functioning. It can be because of a variety of causes. It's important to be aware that you can repair most vehicle keys without having to go to dealers or pay for an locksmith. Here are some typical issues and their easy solutions. Keys Broken or lost You want your car to be running quickly following a key break.