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and supplements resulted in beneficial hepatoprotective effects in horses treated with imidocarb dipropionate. C scolymus and S marianum supplements resulted in beneficial hepatoprotective effects in horses treated with imidocarb dipropionate. The study determines the pharmacokinetic profiles of dexmedetomidine (DEX), ketamine (KET) and its active metabolite, norketamine (NORKET), after simultaneous administration. Moreover, the study evaluates the sedative effects of this protocol, its influence on the main physiological variables and