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he crosstalk between tumor cells and microenvironment. CONCLUSIONS Taken together, our results show that melanoma-specific bcl-2 controls an IL-1β-driven axis of macrophage diversion that establishes tumor microenvironmental conditions favoring melanoma development. Interfering with this pathway might provide novel therapeutic strategies. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.BACKGROUND Adoptive cellular therapy (ACT) is a promising treatment for synovial sarcoma (SS) with reported respon