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The typical annual incidence of cryptococcosis in Colombia is 0.23 cases per 100,000 residents in the basic population, and 1.1 instances per 1000 in residents with Acquired Immune Deficiency Syndrome (AIDS). In addition, the causal fungus was isolated through the environment, with serotypes A-B and C in various regions. This study aims to determine the hereditary relationship between clinical and ecological isolates of C. neoformans/C. gattii in Colombia. A total of 110 strains, both
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