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ial illness, and that neurological, gastrointestinal, and cardiopulmonary/fatigue symptoms during the ongoing illness, predicted experience of cognitive symptoms. The histamine type 1 receptor antagonist (H1RA) has been commonly used. This study aimed to examine the association between the usage of H1RA and the risk of dementia. A total of 8,986 H1RA users aged ≥50 and 26,958 controls matched a ratio of 13 for age, sex, and comorbidity, were selected between January 1, and December 31, 2000, from Taiwan's National Health Insurance Resea