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GGC, OR = 2.38, 95% CI, 1.53-3.75, P less then 0.001; CGG vs. GGC, OR = 3.76, 95% CI, 2.12-6.68, P less then 0.001). Dual-luciferase reporter assay showed that the rs1041279 G promoter resulted in higher transcriptional activity compared with the rs1041279 C (P less then 0.01). Additionally, the rs1041279 GG genotype carriers had an increased level of HULC expression (P = 0.03). These findings suggest that the HULC rs1041279 may be a useful marker for the etiology of CSCC.Prenatal testosterone (T) excess, partly via androgenic programmin