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16, 95% confidence interval (CI) 1.13-1.19 for those in KC PRS quartile 4 compared with those in quartile 1. In the two-sample approach, the pooled risk of developing other cancers was statistically significantly elevated, with an OR of 1.05, 95% CI 1.03-1.07 per doubling in the odds of KC. We observed similar trends of increasing cancer risk with increasing KC PRS in the QSkin cohort. Two different genetic approaches provide compelling evidence that an instrumental variable for KC constructed from genetic variants predicts the risk of ca