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Women also had more frequently cirrhosis at diagnosis and required LT more often than men. The epidemiology of PSC is changing. The number of women affected is greater than what was expected from the literature, with a recent increase in incidence. There seems to be differences between sexes in the form of presentation and disease course that should be confirmed in subsequent studies. The epidemiology of PSC is changing. The number of women affected is greater than what was expected from the literature, with a recent increase in inc