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Further, CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 phenotype. Overall, these findings suggest that CHA-encapsulated mannosylated liposomes have actually great potential to improve the immunotherapeutic efficacy of CHA by inducing a shift from the M2 into the M1 phenotype.Naked mole-rats (Heterocephalus glaber) have actu