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The effect of high flow oxygen (HFOx) and high flow air (HFAir) on dyspnea in non-hypoxemic patients is not known. We assessed the effect of HFOx, HFAir, low flow oxygen (LFOx) and low flow air (LFAir) on dyspnea. This double-blind, 4x4 crossover clinical trial enrolled hospitalized patients with cancer who were dyspneic at rest and non-hypoxemic (SpO290% on room air). Patients were randomized to 10 minutes of HFOx, HFAir, LFOx and LFAir in different orders. The flow rate was titrated between 20-60 L/min in the high flow intervention
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