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So that you can further improve the gankyrin binding ability associated with cjoc42 scaffold, an extensive SAR when it comes to aryl-triazole moiety of cjoc42 ended up being developed. Our cjoc42 derivatives exhibited enhanced gankyrin binding, along with improved antiproliferative activity against Hep3B, HepG2, A549, and MDA-MB-231 cancer tumors cell lines.Glucose transporter 2 (GLUT2) is taking part in sugar uptake by hepatocytes, pancreatic beta cells, and absorptive cells in th