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ADHD Medication - Stimulants Stimulants change how the brain releases chemicals that influence concentration. Doctors often start people with ADHD with stimulants and gradually work up to the highest dose that helps them. People who suffer from ADHD also use antidepressants (they're not just for depression). These drugs work with the same chemicals as stimulants, but have fewer negative side effects. Stimulants The first medication that doctors prescribe for ADHD is stimulants. They increase levels of dopamine and other neurotransmitter-hormones that