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PRACTICAL APPLICATIONS Apigenin, apigetrin, and luteolin are understood biologically active compounds contained in celery. Acid hydrolysis could raise the biologically active substances in organic products. The study investigated the consequences of acid HCE in a mice type of atopic dermatitis. The data acquired from this research sheds light from the usage of hydrolysis solutions to enhance the biological activities of plant extracts utilized in nutraceutical sectors. © 2020 Wiley Periodicals,