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Different sets of practices and techniques, including dermatoscopical examination of this "ABCDE" signs of the lesion, imaging methods or microscopical, immunohistochemical and serological biomarkers can be obtained and utilized nowadays to identify malignant melanoma. Up to now, various biomarkers were suggested for melanoma, but only some, including circulating proteins, such as for example lactate dehydrogenase, molecular and metabolite biomarkers, have reached clinical pro