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The highest penetration of resveratrol into the skin ex vivo was determined from ME with S CoS weight ratio 5 1. It was demonstrated that all MEs were similar in their ability to deliver resveratrol into the skin ex vivo.Podocyte injury is an important mechanism of diabetic nephropathy (DN). Accumulating evidence suggests that nephrin expression is decreased in podocyte in DN. Moreover, it has been demonstrated that tongxinluo (TXL) can ameliorate renal structure disruption and dysfunction in DN. However, the effect of TXL on podocyte i