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Adult ADHD and Comorbid Disorders Many people with ADHD also have comorbid disorders like major depression (Kessler and colleagues, 2006). Many people who suffer from depression do not respond well to medication and may benefit from therapy. that most effectively improve core symptoms of ADHD are those that boost and balance levels of certain neurotransmitters, which are brain chemicals. Commonly prescribed stimulants include methylphenidate, amphetamine and other similar drugs. Medicines Many of the