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In this study, we aim to compare spatial statistic models to estimate the spatial distribution of Zika and Chikungunya infections in the city of Recife, Brazil. We also aim to establish the relationship between the diseases and the analyzed geographical conditions. The models were defined by combining three categories type of spatial unit, calculation of the dependent variable format, and estimation methods (Geographical Weighted Regression [GWR] and Ordinary Least Square [OLS]). We identified the most accurate model to estimate the s