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The circulated sulfhydryl group in the peptide can readily be utilized for cyclization regarding the peptide library with bis-electrophilic linker reagents.The enzymatic-assisted sign amplification of DNA sensors is rarely applied in residing cells as a result of the problems in necessary protein distribution. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.In thi