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In addition, 1% O2-induced increases in lactate concentration and glucose uptake were also repressed by HIF1A silencing. Next, by analyzing available information in TCGA, we found that lncRNA RAET1K ended up being correlated with HIF1A and miR-100-5p.LncRNA RAET1K could downregulate the expression of miR-100-5p by acting as a sponge, while HIF1A bound the lncRNA RAET1K promoter area to stimulate its transcription. LncRNA RAET1K silencing dramatically suppressed HCC c